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Modulation of folic acid bioaccessibility by encapsulation in pH-responsive gated mesoporous silica particles

2015

[EN] A study on the controlled release of folic acid (FA) from pH-responsive gated mesoporous silica particles (MSP) is reported. The MCM-41 support was synthesized using tetraethyl orthosilicate (TEOS) as hydrolytic inorganic precursor and the surfactant hexadecyltrimethylammonium bromide (CTAB) as porogen species. Calcination of the mesostructured phase resulted in the starting solid. This solid was loaded with FA to obtain the initial support S0. Moreover, this FA-loaded material was further functionalized with 3-[2-(2-aminoethylamino)ethylamino]propyltrimethoxysilane (N3) in order to obtain the gated polyamine-functionalised material S1. Solids S0 and S1 were characterized using standar…

INGENIERIA DE LA CONSTRUCCIONFolic acidTECNOLOGIA DE ALIMENTOSBioaccessibilityMesoporous silica particleslaw.inventionchemistry.chemical_compoundHydrolysisQUIMICA ORGANICAPulmonary surfactantlawControlled releaseGeneral Materials ScienceCalcinationLoading optimizationChromatographyChemistryQUIMICA INORGANICAGeneral ChemistryMesoporous silicaCondensed Matter PhysicsControlled releaseTetraethyl orthosilicateMechanics of MaterialsSurface modificationMesoporous materialNuclear chemistry
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